منابع مشابه
A vertebrate fatty acid desaturase with 5 and 6 activities
5 and 6 fatty acid desaturases are critical enzymes in the pathways for the biosynthesis of the polyunsaturated fatty acids arachidonic, eicosapentaenoic, and docosahexaenoic acids. They are encoded by distinct genes in mammals and Caenorhabditis elegans. This paper describes a cDNA isolated from zebrafish (Danio rerio) with high similarity to mammalian 6 desaturase genes. The 1,590-bp sequence...
متن کاملPurification and function analysis of the Δ-17 fatty acid desaturase with or without transmembrane domain
Fatty acid desaturation enzymes perform dehydrogenation reactions leading to the insertion of double bonds in fatty acids. ω-3 desaturase has an important role in converting ω-6 fatty acids into ω-3 fatty acids. Although genes for this desaturase have been identified, the enzymatic activity of Δ-17 with or without transmembrane domain, and the function of the Δ-17 desaturase is poorly understoo...
متن کاملKnockdown of Δ-5 Fatty Acid Desaturase Is More Than Just a Fad.
Human genome-wide association studies have revealed a large number of genomic loci linked to cardiometabolic disease traits. However, for many of the gene variants identified, it remains unknown how they functionally influence the disease phenotype or whether these genes represent new therapeutic targets. Single-nucleotide polymorphisms in FADS1, which encodes Δ-5 fatty acid desaturase, have be...
متن کاملFatty acid desaturase mutants of Saccharomyces cerevisiae.
Genetic and biochemical analyses were conducted on fatty acid mutants of yeast deficient for Delta(9)-desaturase activity in the production of palmitoleate and oleate. Two genetic loci were observed and two others are inferred; three of these were represented by respiratory-deficient (petite) strains. All strains were incapable of converting palmitate to palmitoleate and stearate to oleate whet...
متن کاملThe fatty acid desaturase 3 gene encodes for different FADS3 protein isoforms in mammalian tissues.
In 2000, Marquardt et al. (A. Marquardt, H. Stöhr, K. White, and B. H. F. Weber. 2000. cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family. Genomics. 66: 176-183.) described the genomic structure of the fatty acid desaturase (FADS) cluster in humans. This cluster includes the FADS1 and FADS2 genes encoding, respectively, for t...
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ژورنال
عنوان ژورنال: Journal of Japan Oil Chemists' Society
سال: 2000
ISSN: 1341-8327,1884-1996
DOI: 10.5650/jos1996.49.3